the correlations between chemical structure properties and antiviral activities of hiv-1 inhibitors: the study of anti-aids
نویسندگان
چکیده
in this work, we calculated the several physico chemical properties containing of solubility (byvcl), lipophilicity (by milinspiration), dipole and quadrupole moments (by density functionaltheory) for 7 azt analogs, and compared these parameters with inhibition assays of them. it isresulted; cytotoxicity of these drugs is related with their lipophilicity inversely. with using of thisresult, for 7 nucleoside analoges we predict, cytotoxicity addition arrangement are as following:cbv> d4t> ddi> azt> ddc> abc> 3tc
منابع مشابه
The correlations between chemical structure properties and antiviral activities of HIV-1 inhibitors: The study of anti-AIDS
In this work, we calculated the several physico chemical properties containing of solubility (byVCL), lipophilicity (by milinspiration), dipole and quadrupole moments (by Density FunctionalTheory) for 7 AZT analogs, and compared these parameters with inhibition assays of them. It isresulted; cytotoxicity of these drugs is related with their lipophilicity inversely. With using of thisresult, for...
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عنوان ژورنال:
journal of physical & theoretical chemistryISSN
دوره 1
شماره 4 2005
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